ChemOrigins: database for Prebiotic Chemistry

This is a compilation of experimentally tested prebiotic pathways to produce biomolecules or molecules relevant for the Origin of Life. ChemOrigins offers access to a comprehensive knowledge graph focused on prebiotic chemistry.

https://doi.org/10.1101/2025.06.10.658922

 

Nitrogenase Structural Database (NSDB):

Nitrogenases are fundamental for our biosphere, as they carry out the only biological mechanism to fix molecular nitrogen. In this database, we provide a massive set of extant and ancestral nitrogenase structural predictions.

https://doi.org/10.7554/eLife.105613.1

 

Candidate autocatalytic cycles for prebiotic chemistry:

The Encyclopedia Autocatalytica is intended to serve as a recipe book; a starting point to learn about autocatalytic chemical reaction sets that lead to the design of new origins of life experiments.

https://doi.org/10.1021/jacs.3c07041

 

Radical experiments for Prebiotic origins (REPO):

A resource bringing together people and knowledge to explore how radicals could have driven life’s origins.